Real-time label-free quantitative monitoring of biomolecules without surface binding by floating-gate complementary metal-oxide semiconductor sensor array integrated with readout circuitry

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We report a label-free field-effect sensing array integrated with complementary metal-oxide semiconductor (CMOS) readout circuitry to detect the surface potential determined by the negative charge in DNA molecules. For real-time DNA quantification, we have demonstrated the measurements of DNA molecules without immobilizing them on the sensing surface which is composed of an array of floating-gate CMOS transistors. This nonimmobilizing technique allows the continuous monitoring of the amount of charged molecules by injecting DNA solutions sequentially. We have carried out the real-time quantitative measurement of 19 bp oligonucleotides and analyzed its sensitivity as a function of pH in buffer solutions. (c) 2007 American Institute of Physics.
Publisher
AMER INST PHYSICS
Issue Date
2007-11
Language
English
Article Type
Article
Keywords

FIELD-EFFECT TRANSISTOR; AMPLIFICATION; DEVICE; SYSTEM

Citation

APPLIED PHYSICS LETTERS, v.91, pp.892 - 899

ISSN
0003-6951
DOI
10.1063/1.2803848
URI
http://hdl.handle.net/10203/91778
Appears in Collection
EE-Journal Papers(저널논문)
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