Microfluidic separation of (S)-ibuprofen using enzymatic reaction

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This study was investigated for the enantioselective separation of (S)-ibuprofen using the ionic liquid in the microfluidic device. A stable and thin ionic liquid flow (ILF) was made by controlling the flow rate of the ELF in the microfluidic channel. In addition, coupling lipase as a biocatalyst with the ILF based on the microfluidic device showed the facilitative and selective transport of (S)-ibuprofen across the ILF, indicating successful optical resolution of a racemic mixture. Subsequently, the enantioselectivity was evaluated in the transport ratio (q) of (R)- and (S)-ibuprofen, the optical resolution ratio (alpha) and enantiomeric excess of (S)-ibuprofen (ee(S)). (c) 2006 Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2006-12
Language
English
Article Type
Article; Proceedings Paper
Keywords

SUPPORTED LIQUID-MEMBRANE; IONIC LIQUIDS; MOLECULAR DIAGNOSTICS; RACEMIC IBUPROFEN; ANALYSIS SYSTEMS; LIPASE; HYDROLYSIS; TRANSESTERIFICATION; ESTERIFICATION; INTEGRATION

Citation

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, v.43, no.1-4, pp.96 - 101

ISSN
1381-1177
URI
http://hdl.handle.net/10203/91383
Appears in Collection
CBE-Journal Papers(저널논문)
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