The autonomy of models and explanation: anomalous molecular rearrangements in early twentieth-century physical organic chemistry

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During the 1930s and 1940s, American physical organic chemists employed electronic theories of reaction mechanisms to construct models offering explanations of organic reactions. But two molecular rearrangements presented enormous challenges to model construction. The Claisen and Cope rearrangements were predominantly inaccessible to experimental investigation and they confounded explanation in theoretical terms. Drawing on the idea that models can be autonomous agents in the production of scientific knowledge, I argue that one group of models in particular were functionally autonomous from the Hughes-Ingold theory. Cope and Hardy's models of the Claisen and Cope rearrangements were resources for the exploration of the Hughes-Ingold theory that otherwise lacked explanatory power. By generating 'how-possibly' explanations, these models explained how these rearrangements could happen rather than why they did happen. Furthermore, although these models were apparently closely connected to theory in terms of their construction, I argue that partial autonomy issued in extra-logical factors concerning the attitudes of American chemists to the Hughes-Ingold theory. And in the absence of a complete theoretical hegemony, a degree of consensus was reached concerning modelling the Claisen rearrangement mechanism. (c) 2006 Elsevier Ltd. All rights reserved.
Publisher
ELSEVIER SCI LTD
Issue Date
2006-12
Language
English
Article Type
Article; Proceedings Paper
Keywords

ALLYL; ETHERS; STATES

Citation

STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE, v.37, no.4, pp.562 - 584

ISSN
0039-3681
DOI
10.1016/j.shpsa.2006.09.009
URI
http://hdl.handle.net/10203/90690
Appears in Collection
STP-Journal Papers(저널논문)
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