Working memory processing of facial images in schizophrenia: fMRI investigation

Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with schizophrenia. This study aimed to elucidate the differences in brain activities involved in the process of facial working memory (images of neutral faces as mnemonic content) between schizophrenic patients and healthy comparison subjects using functional magnetic resonance imaging (fMRI). Group comparison analysis revealed aberrant activities from the patient group in several cortical areas, including the left fusiform gyrus, right superior frontal gyrus, bilateral middle frontal gyri/insula, and left middle temporal gyrus. A decreased level of activity in the left fusiform gyrus, along with performance reduction, implicates abnormal processing of facial information in schizophrenia.
Publisher
TAYLOR & FRANCIS LTD
Issue Date
2005-03
Language
ENG
Keywords

DORSOLATERAL PREFRONTAL CORTEX; FACES; RECOGNITION; DYSFUNCTION; DEPRESSION; REDUCTION; AMYGDALA

Citation

INTERNATIONAL JOURNAL OF NEUROSCIENCE, v.115, no.3, pp.351 - 366

ISSN
0020-7454
DOI
10.1080/00207450590520957
URI
http://hdl.handle.net/10203/87735
Appears in Collection
RIMS Journal Papers
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