Asymmetric synthesis of 1,2-amino alcohols using tert-butanesulfinimines as chiral auxiliary

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Facile and highly stereoselective synthesis of 1,2-amino alcohols has been achieved by the addition of [(dimethylphenylsilyl)methyl] magnesium chloride to the tert-butanesulfinimines, followed by Fleming-Tamao oxidation of the silicon moiety.
Publisher
Georg Thieme Verlag Kg
Issue Date
2005-02
Language
English
Article Type
Article
Keywords

BETA-AMINO ALCOHOLS; HYDROGEN-PEROXIDE OXIDATION; ORGANIC-SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; SILAFUNCTIONAL COMPOUNDS; ENANTIOSELECTIVE SYNTHESIS; CARBON BOND; ACIDS; INHIBITOR; IMINES

Citation

SYNLETT, no.2, pp.304 - 308

ISSN
0936-5214
DOI
10.1055/s-2004-836070
URI
http://hdl.handle.net/10203/87051
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