Effects of charge fluctuation on two-membrane instability and fusion

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Membrane fusion is fundamental to diverse biological processes ranging from intercellular and intracellular transport to egg fertilization. We study the effects of coupling between membrane undulation and charge fluctuation on its fusion. We find that, at concentrations of millimolar range, multivalent cations such as calcium in solution induce a strong correlated-charge fluctuation on each membrane, leading to inversion and overcondensation of surface charges. When the charge fluctuation is cooperatively coupled to undulation, two apposing membranes undergo a dynamic instability to spontaneous growth of in-phase undulation with submicron wavelengths, thereby greatly reducing fusion barrier.
Publisher
AMERICAN PHYSICAL SOC
Issue Date
2003-09
Language
English
Article Type
Article
Keywords

RODLIKE POLYELECTROLYTES; MEMBRANE; ATTRACTION

Citation

PHYSICAL REVIEW LETTERS, v.91, no.11, pp.118101

ISSN
0031-9007
DOI
10.1103/PhysRevLett.91.118101
URI
http://hdl.handle.net/10203/85996
Appears in Collection
NT-Journal Papers(저널논문)
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