Oxalate와 Enrofloxacin투여한 랫트신장에 대한 병리조직학적관찰 Histopathological Observations on the Renal Injury in Rats Administered with Enrofloxacin and Oxalate

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dc.contributor.author오원서ko
dc.contributor.author이차수ko
dc.contributor.author오규실ko
dc.contributor.author정원일ko
dc.contributor.author정재용ko
dc.contributor.author정다히ko
dc.contributor.author정규식ko
dc.date.accessioned2013-03-06T04:04:08Z-
dc.date.available2013-03-06T04:04:08Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2003-12-
dc.identifier.citation한국임상수의학회지, v.20, no.4, pp.449 - 457-
dc.identifier.issn1598-298X-
dc.identifier.urihttp://hdl.handle.net/10203/85752-
dc.description.abstractTo investigate the renal effects of enrofloxacin administration on rats induced with dehydration or hyperoxaluria, male rats were treated with enrofloxacin of 50 mg to 500 mg/kg b.w.. The microscopical observations of kidney and urine sediment were carried out in the experimental groups. The result obtained were as follows; The male rats deprived of water for 72 hours and administered with enrofloxacin. As enrofloxacin administration dose was increased, clinical signs such as loss of appetite, depression, weakness, and loss of urine output became more severe. In the histopathological findings, there were hyperemia and hemorrhage in renal cortex, vacuolation and necrosis of renal tubular epithelia, proteinous casts within renal tubules. The male rats were orally administered with sodium oxalate and injected with enrofloxacin for 7days. As enrofloxacin administration dose was increased, clinical signs such as the loss of appetite and water consumption, and weakness became more severe. In the histopathological findings, there are hemorrhage of glomeruli and cortical hyperemia, vacuolation and necrosis of tubular epithelia, proteinous casts in renal tubules. In the microscopical findings of urine sediment, there are calcium oxalate crystal (diamond-like type) and magnesium ammonium phosphate crystals (rhomboid). The male rats were intraperitoneally injected with sodium oxalate and administered with enrofloxacin for 7days. As enrofloxacin administration dose was increased, clinical signs such as the loss of appetite and water consumption, weakness were more severe. In the histopathological findings, there were hyperemia and hemorrhage in both glomeruli and renal cortex. Severe necrosis of renal tubular epithelia, bluish materials within renal tubules were also found. In the microscopical findings of urine sediment, there were many calcium oxalate crystals. The present results suggest that enrofloxacin has some injurious effects in rats having dehydration or hyperoxaluria, and clinically, we should consider these renal injury effects when we use enrofloxacin in patients accompanied renal disease, dehydration and hyperoxaluria conditions.-
dc.languageKorean-
dc.publisher한국임상수의학회-
dc.titleOxalate와 Enrofloxacin투여한 랫트신장에 대한 병리조직학적관찰-
dc.title.alternativeHistopathological Observations on the Renal Injury in Rats Administered with Enrofloxacin and Oxalate-
dc.typeArticle-
dc.type.rimsART-
dc.citation.volume20-
dc.citation.issue4-
dc.citation.beginningpage449-
dc.citation.endingpage457-
dc.citation.publicationname한국임상수의학회지-
dc.identifier.kciidART000891816-
dc.contributor.localauthor정원일-
dc.contributor.nonIdAuthor오원서-
dc.contributor.nonIdAuthor이차수-
dc.contributor.nonIdAuthor오규실-
dc.contributor.nonIdAuthor정재용-
dc.contributor.nonIdAuthor정다히-
dc.contributor.nonIdAuthor정규식-
dc.subject.keywordAuthorrat-
dc.subject.keywordAuthoroxalate-
dc.subject.keywordAuthorenrofloxacin-
dc.subject.keywordAuthorkidney-
dc.subject.keywordAuthorhistopathology-
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