DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Dongkyu | ko |
dc.contributor.author | Lee, Seung-Chul | ko |
dc.contributor.author | Heo, Yong-Seok | ko |
dc.contributor.author | Lee, Woon-Young | ko |
dc.contributor.author | Cho, Yong-Soon | ko |
dc.contributor.author | Kim, Yong Eun | ko |
dc.contributor.author | Hyun, Young-Lan | ko |
dc.contributor.author | Cho, Joong Myung | ko |
dc.contributor.author | Lee, Yoon Sup | ko |
dc.contributor.author | Ro, Seonggu | ko |
dc.date.accessioned | 2009-01-06T06:41:02Z | - |
dc.date.available | 2009-01-06T06:41:02Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-10 | - |
dc.identifier.citation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.20, pp.5686 - 5689 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | http://hdl.handle.net/10203/8225 | - |
dc.description.abstract | A hydroxy functional group was introduced as the hydrogen bond donor and acceptor at the hinge region of protein kinase in order to develop novel ATP-competitive inhibitors. Several derivatives of 7-hydroxyl-1H-benzoimidazole were designed as inhibitors of glycogen synthase kinase-3 beta with the help of ab initio calculations and a docking study. Enzymatic assay and an X-ray complex study showed that these designed compounds were highly potent ATP-competitive inhibitors. (c) 2007 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | This work was partially supported by Yuyu, Inc. as well as by the National Research Laboratory Program of MOST (Ministry of Science and Technology) and MOCIE(Ministry of Commerce, Industry and Energy) of Korea and Medium-term Strategic Technology Development Program of MOICE. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | SKELETAL-MUSCLE | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | MECHANISM | - |
dc.subject | BETA | - |
dc.subject | MICE | - |
dc.title | Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3 beta | - |
dc.type | Article | - |
dc.identifier.wosid | 000250287600040 | - |
dc.identifier.scopusid | 2-s2.0-34548608549 | - |
dc.type.rims | ART | - |
dc.citation.volume | 17 | - |
dc.citation.issue | 20 | - |
dc.citation.beginningpage | 5686 | - |
dc.citation.endingpage | 5689 | - |
dc.citation.publicationname | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.identifier.doi | 10.1016/j.bmcl.2007.07.056 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, Yoon Sup | - |
dc.contributor.nonIdAuthor | Shin, Dongkyu | - |
dc.contributor.nonIdAuthor | Lee, Seung-Chul | - |
dc.contributor.nonIdAuthor | Heo, Yong-Seok | - |
dc.contributor.nonIdAuthor | Lee, Woon-Young | - |
dc.contributor.nonIdAuthor | Cho, Yong-Soon | - |
dc.contributor.nonIdAuthor | Kim, Yong Eun | - |
dc.contributor.nonIdAuthor | Hyun, Young-Lan | - |
dc.contributor.nonIdAuthor | Cho, Joong Myung | - |
dc.contributor.nonIdAuthor | Ro, Seonggu | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | kinase inhibitor | - |
dc.subject.keywordAuthor | drug design | - |
dc.subject.keywordAuthor | glycogen synthase kinase | - |
dc.subject.keywordAuthor | GSK | - |
dc.subject.keywordAuthor | 7-hydroxy-1H-benzoimidazole | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | MICE | - |
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