Kaposis sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosis

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Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 50 (ORF50) encodes a viral transcriptional activator which stimulates the transcription of viral early and late genes of KSHV. Here we show that ORF50 represses transcriptional activity of p53 and p53-induced apoptosis through interaction with CREB binding. protein (CBP). This inhibitory effect of ORF50 on the transcriptional activity of p53 was relieved by the addition of CBP. ORF50 mutants, which are defective in interaction with CBP, lost the inhibitory effects on p53. Our data provide a framework for delineating the regulatory mechanisms used by KSHV to modulate cellular transcription and the cell cycle.
Publisher
Amer Soc Microbiology
Issue Date
2001-07
Language
English
Article Type
Article
Keywords

COACTIVATOR CBP; PROTEIN; P53; IDENTIFICATION; TRANSACTIVATOR; REACTIVATION; ACTIVATION; EXPRESSION; P300; TAX

Citation

JOURNAL OF VIROLOGY, v.75, no.13, pp.6245 - 6248

ISSN
0022-538X
URI
http://hdl.handle.net/10203/78875
Appears in Collection
BS-Journal Papers(저널논문)
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