초임계 이산화탄소와 보조용매를 이용한 주목잎에서의 Taxol과 Baccatin III의 추출 Extraction of Taxol and Baccatin III from Needles of Taxus Cuspidata by Using Supercritical Carbon Dioxide with Cosolvents

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The extraction of taxol and baccatin III from the ground needles of Taxus cuspidata were carried out by using supercritical carbon dioxide with and without cosolvents such as ethylacetate and methanol at 300 bar and 313K. Taxol is a promising anticancer agent and baccatin III is a precursor of semisysthesis of taxol. The taxol and baccatin III contents in the extracts were determined by a HPLC. The highest yields of taxol and baccatin III could be obtained by the supercritical extraction with 3wt% methanol and ethylacetate, respectively, as cosolvents. It was also found that the selectivity of taxol and baccatin III were 0.117 and 1.245wt%, respectively, with 0.7wt% ethylacetate, which demonstrated that the selectivity of taxol and baccatin III were increased about 1.8 and 19 times than those of conventional organic solvent extraction.
Publisher
한국생물공학회
Issue Date
1996-04
Language
Korean
Citation

KSBB JOURNAL, v.11, no.1, pp.100 - 106

ISSN
1225-7117
URI
http://hdl.handle.net/10203/75277
Appears in Collection
CBE-Journal Papers(저널논문)
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