Heterogeneity of human papillomavirus DNA in a patient with Bowenoid papulosis that progressed to squamous cell carcinoma

Bowenoid papulosis (BP) of the genitalia, characterized by the histological Endings of a squamous cell carcinoma, follows a largely benign clinical course. The detection of oncogenic human papilloma viruses (HPV) from BP points to an aetiological role of these viral infections. A 47-year-old man with multiple genital skin lesions was seen over a 10-year period with the diagnosis of BP. Recently, he attended again with a recurrent genital tumour that was diagnosed as squamous cell carcinoma. His genital lesions progressed and became polymorphic in appearance, from a wart-like tumour to a reddish invasive plaque. To screen for the presence of different HPV sequences from different skin lesions and to correlate each HPV type with distinct clinical manifestations, polymerase chain reaction and single-strand conformational polymorphism (PCR-SSCP) were performed, PCR-SSCP revealed the presence of several types of HPV from different genital lesions. Sequencing results disclosed that he had a mixed infection of HPV6b, HPV16, HPV18 and HPV33, respectively. Interestingly, the clinical findings were fairly well correlated with the oncogenic potential of HPV found from each lesion.
Publisher
BLACKWELL SCIENCE LTD
Issue Date
1998-12
Language
ENG
Keywords

POLYMERASE CHAIN-REACTION; NUCLEOTIDE-SEQUENCE; DISEASE; ATYPIA

Citation

BRITISH JOURNAL OF DERMATOLOGY, v.139, no.6, pp.1087 - 1091

ISSN
0007-0963
URI
http://hdl.handle.net/10203/74847
Appears in Collection
BS-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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