The K-bZIP Protein from Kaposis Sarcoma-Associated Herpesvirus Interacts with p53 and Represses Its Transcriptional activity

Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that has been implicated in the pathogenesis of Kaposi's sarcoma. KSHV encodes K-bZIP (open reading frame K8), a protein that belongs to the basic region-leucine zipper (bZIP) family of transcription factors. Here we show that K-bZIP associates with the cellular transcription factor p53 directly in vitro and in vivo. This interaction requires the bZIP domain of K-bZIP and the carboxy-terminal region (amino acids 300 to 393) of p53. We also show that K-bZIP represses the transcriptional activity of p53 which is required for apoptosis of the host cell. These results imply that K-bZIP blocks p53-mediated host cell death through its interaction with p53.
Publisher
Amer Soc Microbiology
Issue Date
2000-12
Language
ENG
Keywords

EPSTEIN-BARR-VIRUS; GENE-EXPRESSION; DNA-SEQUENCES; VIRAL-DNA; BZLF1; PROMOTER; GROWTH; BINDS; AP-1; ZTA

Citation

JOURNAL OF VIROLOGY, v.74, no.24, pp.11977 - 11982

ISSN
0022-538X
URI
http://hdl.handle.net/10203/74799
Appears in Collection
BS-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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