중증근무력증 환자의 말초 혈액내 T림프구 분획의 변화 Analysis of the T Lymphocyte Subsets in the Peripheral Blood of Patients with Myasthenia Gravis

It is known that the activated peripheral T lymphocytes are increased in patients with autoimmune disorders such as systemic lupus erythematosis, rheumatoid arthritis, multiple sclerosis and autoimmune thyroiditis, but not in the patients with myasthenia gravis on previous studies. We investigated the subsets of T cells in peripheral blood of the patients with myasthenia gravis using flow cytometric analysis. Forty-three patients of myasthenia gravis who were not on steroid or other immunosuppressants were chosen, and thirty-six age-matched healthy persons were evaluated as controls. The peripheral blood mononuclear cells from patients and controls were stained with FITC or PE-conjugated monoclonal antibodies to several surface molecules expressed on T cells within 6 hours after collection. The samples were analysed by flow cytometry within 24 hours. In patients with myasthenia gravis, the expressions of DR and CD25 molecules on the T lymphocytes were increased significantly compared to those of the control group. The expression of CD25 was increased on CD4+ T cells, but not on CD8+ T cells . The expression of DR molecule was increased on CD8+ T cells, but not on CD4+ T cells. Therefore we suggest that the activated T cells are increased in myasthenia gravis and CD25 surface markers on CD4+ T cells may be a more sensitive indicator of immune status. Key words : Myasthenia gravis; T lymphocytes; DR molecule; Interleukin 2 receptor; Flow cytometry
Publisher
대한신경과학회
Issue Date
1998-01
Language
KOR
Citation

대한신경과학회지, v.16, no.1, pp.49 - 54

ISSN
1225-7044
URI
http://hdl.handle.net/10203/74758
Appears in Collection
BiS-Journal Papers(저널논문)
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