An asymmetric synthetic route to (+)-lactacystin

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Trihydroxy pyrrolidinone 16, a key intermediate to (+)-lactacystin 1, has been stereoselectively synthesized via the highly diastereoselective crotylboration of aldehyde 5 and intramolecular mercurioamidation of allylic trichloroacetimidate 12 to introduce the three requisite contiguous chiral centers of methyl, hydroxy and amino substituents.
Publisher
GEORG THIEME VERLAG
Issue Date
1998-10
Language
English
Article Type
Article
Keywords

MICROBIAL METABOLITE; NEUROBLASTOMA-CELLS; LACTACYSTIN; ALDEHYDES

Citation

SYNLETT, pp.1045 - 1045

ISSN
0936-5214
URI
http://hdl.handle.net/10203/74428
Appears in Collection
CH-Journal Papers(저널논문)
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