Subthreshold facilitation and suppression in primary visual cortex revealed by intrinsic signal imaging

Cited 132 time in webofscience Cited 138 time in scopus
  • Hit : 347
  • Download : 0
Neurons in primary visual cortex (area 17) respond vigorously to oriented stimuli within their receptive fields; however, stimuli presented outside the suprathreshold receptive field can also influence their responses. Here we describe a fundamental feature of the spatial interaction between suprathreshold center and subthreshold surround. By optical imaging of intrinsic signals in area 17 in response to a stimulus border, we show that a given stimulus generates activity primarily in iso-orientation domains, which extend for several millimeters across the cortical surface in a manner consistent with the architecture of long-range horizontal connections in area 17. By mapping the receptive fields of single neurons and imaging responses from the same cortex to stimuli that include or exclude the aggregate suprathreshold receptive field, we show that intrinsic signals strongly reveal the subthreshold surround contribution. Optical imaging and single-unit recording both demonstrate that the relative contrast of center and surround stimuli regulates whether surround interactions are facilitative or suppressive: the same surround stimulus facilitates responses when center contrast is low, but suppresses responses when center contrast is high. Such spatial interactions in area 17 are ideally suited to contribute to phenomena commonly regarded as part of ''higher-level'' visual processing, such as perceptual ''popout'' and ''filling-in.''
Publisher
NATL ACAD SCIENCES
Issue Date
1996-09
Language
English
Article Type
Article
Keywords

MACAQUE STRIATE CORTEX; ORIENTATION SELECTIVITY; RETINOTOPIC ORGANIZATION; FUNCTIONAL ARCHITECTURE; HORIZONTAL CONNECTIONS; FIELD SIZE; CAT; NEURONS; MONKEY; RESPONSES

Citation

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.93, no.18, pp.9869 - 9874

ISSN
0027-8424
DOI
10.1073/pnas.93.18.9869
URI
http://hdl.handle.net/10203/73661
Appears in Collection
EE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 132 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0