High-resolution mapping of iso-orientation columns by fMRI

Blood-oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is an important tool for localizing brain functions in vivo. However, the ability of BOLD fMRI to map cortical columnar structures is highly controversial, as the ultimate functional specificity of BOLD remains unknown. Here we report a biphasic BOLD response to visual stimulation in the primary visual cortex of cats. In functional imaging, the initial BOLD signal decrease accurately labeled individual iso-orientation columns. In contrast, the delayed positive BOLD changes indicated the pattern of overall activation in the visual cortex, but were less suited to discriminate active from inactive columns.
Publisher
NATURE AMERICA INC
Issue Date
2000-02
Language
ENG
Keywords

CAT VISUAL-CORTEX; FUNCTIONAL-ORGANIZATION; SENSORY STIMULATION; INTRINSIC SIGNALS; OCULAR DOMINANCE; NEURONAL-ACTIVITY; STRIATE CORTEX; BRAIN ACTIVITY; BLOOD-FLOW; SELECTIVITY

Citation

NATURE NEUROSCIENCE, v.3, no.2, pp.164 - 169

ISSN
1097-6256
URI
http://hdl.handle.net/10203/73658
Appears in Collection
EE-Journal Papers(저널논문)
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