AN ASYMMETRIC-SYNTHESIS OF A KEY INTERMEDIATE TO 1-BETA-METHYLCARBAPENEM ANTIBIOTICS

1 beta-Methylcarbapenem 3 has been enantioselectively synthesized starting from ethoxyethyl ether 8 and methyl (R)-3-iodo-2-methylpropionate via the intramolecular 1,3-dipolar cycloaddition of nitrone 6, in which the requisite chiral centers were settled.
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Issue Date
1995-09
Language
ENG
Keywords

STEREOCONTROLLED SYNTHESIS; HOMOENOLATE; NITRONE

Citation

TETRAHEDRON LETTERS, v.36, no.37, pp.6713 - 6716

ISSN
0040-4039
URI
http://hdl.handle.net/10203/71748
Appears in Collection
CH-Journal Papers(저널논문)
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