Regioselective alkylation and arylation at the 6-position of pyrimidine: Synthesis of 5-alkyl-6-arylmethyl-2,4-pyrimidinediones

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5-Alkyl-2,4,6-trichloropyrimidines reacted with various nucleophiles to afford the regioselectively 6-substituted pyrimidines as the major products in good yields, which were transformed to 5-alkyl-6-arylmethyl-2,4-pyrimidinediones of a key intermediate of MKC-442.
Publisher
MARCEL DEKKER INC
Issue Date
1999
Language
English
Article Type
Article
Keywords

SELECTIVE ANTI-HIV-1 AGENTS; ANTI-HIV ACTIVITY; 1-< (2-HYDROXYETHOXY)METHYL> -6-(PHENYLTHIO)THYMINE HEPT; ANTIVIRAL ACTIVITY; ANALOGS; POTENT; DERIVATIVES

Citation

SYNTHETIC COMMUNICATIONS, v.29, no.9, pp.1503 - 1517

ISSN
0039-7911
DOI
10.1080/00397919908086130
URI
http://hdl.handle.net/10203/71609
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