Involvement of retinoblastoma protein in p27Kip1-induced apoptosis
p27(Kip1), a cyclin-dependent kinase (CDK) inhibitor, plays a critical role in cell cycle regulation. Expression of p27(Kip1) is shown to increase during apoptosis in mammalian cells. Here, to directly address the role of p27(KiP1) in apoptosis, p27(Kip1) is overexpressed in human SK-Hep1 hepatoma cells. This leads to apoptotic cell death and this reduces protein, but not mRNA, levels of the retinoblastoma (Rb). Consistently, accumulation of Rb protein blocks p27(Kip1)-mediated apoptosis. These studies demonstrate an involvement of Rb in the apoptotic cell death which is induced by overexpression of p27(Kip1). (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
- Publisher
- Elsevier Ireland Ltd
- Issue Date
- 2000-01
- Language
- English
- Article Type
- Article
- Keywords
DEPENDENT KINASE INHIBITOR; CELL-CYCLE ARREST; C-MYC; CARCINOMA; INDUCTION; CLEAVAGE; DEATH; BETA; OVEREXPRESSION; ACTIVATION
- Citation
CANCER LETTERS, v.148, no.1, pp.105 - 110
- ISSN
- 0304-3835
- Appears in Collection
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