A New Chiral Synthetic Route to (+)-Isocarbacyclin

A synthetic route to (+)-isocarbacyclin starting from (-)-tricyclo[3.3.0.0(2,8)]octan-3-one 6 is described. The key intermediate 4 has been synthesized from 6 by a sequential introduction of methoxycarbonyl group at C-12 and the oxygen functionality at C-9alpha (PG numbering) for the construction of alpha- and omega-side chain, and then converted to isocarbacyclin methyl ester 2.
Publisher
Korean Chemical Soc
Issue Date
1993
Language
ENG
Keywords

BUILDING-BLOCKS; (+)-9(0)-METHANO-DELTA-6(9-ALPHA)-PGI1; PROSTACYCLIN

Citation

BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.14, no.1, pp.86 - 91

ISSN
0253-2964
URI
http://hdl.handle.net/10203/65601
Appears in Collection
RIMS Journal Papers
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