Induction of electrophilic Metabolites of PAH by placental microsomes in mice

Metabolism of benzo(a)pyrene, the most thoroughly studied PAH, was studied in mouse placental microsomes incubated with (3)H-labeled B(a)P. B(a)P metabolites were separated using HPLC fitted with a C18-micro Bondapak column. The single major metabolite by mouse placental microsomes induced by B(a)P was 7,8-diol B(a)P, while 4,5-diol B(a)P, 3-OH and quinones constituted minor metabolites. Treatment with 3-methyl-cholanthrene to mice resulted in induction of hydroxy B(a)P and quinore compounds. Phenobarital treated mouse placental microsomes also showed elevated level of B(a)P metabolism with 7,8-diol B(a)P as a major metabolite
Publisher
한국동물학회
Issue Date
1988-01
Language
ENG
Citation

THE KOREAN JOURNAL OF ZOOLOGY, v.31, no.2, pp.142 - 146

ISSN
0440-2510
URI
http://hdl.handle.net/10203/59512
Appears in Collection
NE-Journal Papers(저널논문)
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