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College of Life Science and Bioengineering(생명과학기술대학)Graduate School of Medical Science & Engineering(의과학대학원)MSE-Journal Papers(저널논문)

Antielastin autoimmunity in tobacco smoking-induced emphysema

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dc.contributor.authorLee, Seung-Hyoko
dc.contributor.authorGoswami, Sangeetako
dc.contributor.authorGrudo, Arielko
dc.contributor.authorSong, Li-zhenko
dc.contributor.authorBandi, Venkatako
dc.contributor.authorGoodnight-White, Sheilako
dc.contributor.authorGreen, Lindako
dc.contributor.authorHacken-Bitar, Joanko
dc.contributor.authorHuh, Josephko
dc.contributor.authorBakaeen, Faisalko
dc.contributor.authorCoxson, Harvey O.ko
dc.contributor.authorCogswell, Sebastianko
dc.contributor.authorStorness-Bliss, Claudineko
dc.contributor.authorCorry, David B.ko
dc.contributor.authorKheradmand, Farrahko
dc.date.accessioned2008-07-14T08:32:59Z-
dc.date.available2008-07-14T08:32:59Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2007-05-
dc.identifier.citationNATURE MEDICINE, v.13, no.5, pp.567 - 569-
dc.identifier.issn1078-8956-
dc.identifier.urihttp://hdl.handle.net/10203/5762-
dc.description.abstractChronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T(H)1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.-
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectOBSTRUCTIVE PULMONARY-DISEASE-
dc.subjectELASTIN-
dc.subjectAIRWAYS-
dc.subjectHEALTH-
dc.titleAntielastin autoimmunity in tobacco smoking-induced emphysema-
dc.typeArticle-
dc.identifier.wosid000246302800023-
dc.identifier.scopusid2-s2.0-34249652351-
dc.type.rimsART-
dc.citation.volume13-
dc.citation.issue5-
dc.citation.beginningpage567-
dc.citation.endingpage569-
dc.citation.publicationnameNATURE MEDICINE-
dc.identifier.doi10.1038/nm1583-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorLee, Seung-Hyo-
dc.contributor.nonIdAuthorGoswami, Sangeeta-
dc.contributor.nonIdAuthorGrudo, Ariel-
dc.contributor.nonIdAuthorSong, Li-zhen-
dc.contributor.nonIdAuthorBandi, Venkata-
dc.contributor.nonIdAuthorGoodnight-White, Sheila-
dc.contributor.nonIdAuthorGreen, Linda-
dc.contributor.nonIdAuthorHacken-Bitar, Joan-
dc.contributor.nonIdAuthorHuh, Joseph-
dc.contributor.nonIdAuthorBakaeen, Faisal-
dc.contributor.nonIdAuthorCoxson, Harvey O.-
dc.contributor.nonIdAuthorCogswell, Sebastian-
dc.contributor.nonIdAuthorStorness-Bliss, Claudine-
dc.contributor.nonIdAuthorCorry, David B.-
dc.contributor.nonIdAuthorKheradmand, Farrah-
dc.type.journalArticleArticle-
dc.subject.keywordPlusOBSTRUCTIVE PULMONARY-DISEASE-
dc.subject.keywordPlusELASTIN-
dc.subject.keywordPlusAIRWAYS-
dc.subject.keywordPlusHEALTH-
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