Antielastin autoimmunity in tobacco smoking-induced emphysema

Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T(H)1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2007-05
Language
ENG
Keywords

OBSTRUCTIVE PULMONARY-DISEASE; ELASTIN; AIRWAYS; HEALTH

Citation

NATURE MEDICINE, v.13, no.5, pp.567 - 569

ISSN
1078-8956
DOI
10.1038/nm1583
URI
http://hdl.handle.net/10203/5762
Appears in Collection
MSE-Journal Papers(저널논문)
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