DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seung-Hyo | ko |
dc.contributor.author | Prince, J.E. | ko |
dc.contributor.author | Rais, M. | ko |
dc.contributor.author | Kheradmand, F. | ko |
dc.contributor.author | Shardonofsky, F. | ko |
dc.contributor.author | Lu, H. | ko |
dc.contributor.author | Beaudet, A.L. | ko |
dc.contributor.author | Smith, C.W. | ko |
dc.contributor.author | Soong, L. | ko |
dc.contributor.author | Corry, D.B. | ko |
dc.date.accessioned | 2008-07-14T07:02:08Z | - |
dc.date.available | 2008-07-14T07:02:08Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2003-10 | - |
dc.identifier.citation | NATURE MEDICINE, v.9, no.10, pp.1281 - 1286 | - |
dc.identifier.issn | 1078-8956 | - |
dc.identifier.uri | http://hdl.handle.net/10203/5732 | - |
dc.description.abstract | To understand the integrin requirements of T-helper (TH) effector subsets, we investigated the contribution of CD18 (β2 integrin) to TH1 and TH2 function in vitro and in relevant disease models. CD18-deficient (Itgb2) T cells showed largely normal in vitro function. Compared with wild-type mice, Itgb2 mice were better able to resolve Leishmania major infection and generated a superior TH1 immune response, as assessed from draining lymph nodes. In contrast, TH2-dependent allergic lung disease was markedly impaired in mutant mice. In both models, development of TH1 and TH2 cells in spleens was normal, but accumulation of T H2 (not TH1) cells at inflammatory sites was reduced. Thus, CD18 is selectively required for TH2, but not TH1, homing and has a minimal influence on T-effector development. These findings suggest a new integrin-based therapeutic approach in which the outcomes of diverse diseases may be favorably influenced by altering the homing of T H2 cells. | - |
dc.description.sponsorship | This work was supported by grants HL69585-01 (to D.B.C.), HL64061-01 (to F.K.) and F32-HL09657-02 (to H.L.) from the National Institutes of Health. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Nature Publishing Group | - |
dc.title | Differential requirement for CD18 in T-helper effector homing | - |
dc.type | Article | - |
dc.identifier.scopusid | 2-s2.0-10744230101 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.issue | 10 | - |
dc.citation.beginningpage | 1281 | - |
dc.citation.endingpage | 1286 | - |
dc.citation.publicationname | NATURE MEDICINE | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, Seung-Hyo | - |
dc.contributor.nonIdAuthor | Prince, J.E. | - |
dc.contributor.nonIdAuthor | Rais, M. | - |
dc.contributor.nonIdAuthor | Kheradmand, F. | - |
dc.contributor.nonIdAuthor | Shardonofsky, F. | - |
dc.contributor.nonIdAuthor | Lu, H. | - |
dc.contributor.nonIdAuthor | Beaudet, A.L. | - |
dc.contributor.nonIdAuthor | Smith, C.W. | - |
dc.contributor.nonIdAuthor | Soong, L. | - |
dc.contributor.nonIdAuthor | Corry, D.B. | - |
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