A sensitive and simplified HPLC analysis for the determination of fluconazol in human plasma

Abstract

A sensitive and simplified HPLC assay of fluconazol is described. The calibration curve of fluconazol in plasma ranging 0-10 μ g/m l was linear with the correlation coefficients of 0.9900. The limit of detection was 0.3 μ g/m l. The average recovery of the drug was 89.1±9.05%. After oral administration of single dose(150mg) of fluconazol in man, Cmax and Tmax were 3 μg/m l and 4hr., respectively. © 1988 The Pharmaceutical Society of Korea.