The rat-brain postsynaptic density fraction contains a homolog of the drosophila disk-large tumor supressor protein

In CNS synapses, the synaptic junctional complex with associated postsynaptic density is presumed to contain proteins responsible for adhesion between pre- and postsynaptic membranes and for postsynaptic signal transduction. We have found that a prominent, brain-specific protein (PSD-95) enriched in the postsynaptic density fraction from rat brain is highly similar to the Drosophila lethal(1)discs-large-1 (dlg) tumor suppressor protein. The dlg protein is associated with septate junctions in developing flies and contains a guanylate kinase domain that is required for normal control of cell division. The sequence similarity between dlg and PSD-95 suggests that molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain.
Publisher
CELL PRESS
Issue Date
1992-11
Language
ENG
Keywords

LONG-TERM POTENTIATION; CENTRAL NERVOUS-SYSTEM; AMINO-ACID SEQUENCE; SIGNAL TRANSDUCTION; GUANYLATE KINASE; BINDING PROTEIN; CALMODULIN; DNA; IDENTIFICATION; JUNCTIONS

Citation

NEURON, v.9, no.5, pp.929 - 942

ISSN
0896-6273
DOI
10.1016/0896-6273(92)90245-9
URI
http://hdl.handle.net/10203/57266
Appears in Collection
BS-Journal Papers(저널논문)
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