In vitro release and in vivo anti-tumor efficacy of doxorubicin from biodegradable temperature-sensitive star-shaped PLGA-PEG block copolymer hydrogel

Doxorubicin (DXR) was loaded into two kinds of thermo-responsive biodegradable star-shaped block copolymer (4arm PLGA-PEG) solutions with different PLGA block lengths under various conditions (drug-concentrations, polymer-concentrations and block compositions). All release profiles of DXR from star-block copolymer hydrogels showed sustained patterns. To assess this polymer as a sustained drug-delivery formulation, in vivo anti-tumor efficacy was examined by using tumor-bearing mice treated with DXR-loaded/DXR-free hydrogels based on the result of the release study. After I month, the mice treated with DXR-loaded S11-C1 and DXR-loaded S9-C1 copolymer solutions had remarkably suppressed tumor-volume compared to that of the mice treated with DXR-free copolymer solution. And DXR-loaded S11 hydrogel showed more significant tumor inhibition due to the different hydrophobicity between S9 and S11 copolymers. In vitro release and in vivo anti-tumor activity studies performed for 1 month revealed the potential of this hydrogel as a sustained and long-term drug delivery carrier.
Publisher
Nature Publishing Group
Issue Date
2008-02
Language
ENG
Keywords

GEL TRANSITION BEHAVIOR; TRIBLOCK COPOLYMER; AQUEOUS-SOLUTIONS; DRUG-RELEASE; DELIVERY; WATER; POLOXAMER-407; GELATION; MICELLE; SYSTEM

Citation

POLYMER JOURNAL, v.40, no.2, pp.171 - 176

ISSN
0032-3896
URI
http://hdl.handle.net/10203/5239
Appears in Collection
CBE-Journal Papers(저널논문)
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