Synthesis of α-chloroketones from secondary alcohols using dichloramine-T = 이차 알코올로부터 다이클로라민-티를 이용한 알파클로로케톤의 합성

Various secondary alcohols reacted with dichloramine-T in $CH_3CN$ at $40^{\circ}C$ to give the corresponding α-chloroketones in good yields under mild and neutral conditions. This new method for the synthesis of α-chloroketones from secondary alcohol was accomplished by oxidation of secondary alcohols with dichloramine-T and then $\underline{in}$ $\underline{situ}$., followed by α-chlorination of the ketone. The reaction rate is strongly dependent on the nature of the substrate and substituent on the pheny ring moiety. Among the various solvents, acetonitrile showed by best results. The key to the success of this method appears to use aprotic polar solvent such as acetonitrile.
Advisors
Kim, Yong-Haeresearcher김용해researcher
Publisher
한국과학기술원
Issue Date
1990
Identifier
67106/325007 / 000881362
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 화학과, 1990.2, [ v, 47 p. ]

URI
http://hdl.handle.net/10203/32577
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=67106&flag=t
Appears in Collection
CH-Theses_Master(석사논문)
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