Synthesis of ethynyl phosphonates via enolphosphate intermediates = 에놀 포스페이트 중간체를 이용한에티닐포스포네이트의 합성

The facile conversions of $\beta$ -keto phosphonates to various-substituted ethynylphosphonates were studied. By the condensation reactions of diethyl methylphosphonate and acyl chlorides with 2-equivalents of n-BuLi base, the $\beta$ -keto phosphonates were prepared conveniently. In one pot processes, these $\beta$ -keto phosphonates were existed as Li-enolate forms, and subsequent phosphorylation to carbonyl oxygen gave the enol phosphates in stereoselective manners. This diethyl phosphate group was easily eliminated to produce the ethynyl phosphonates by tBuOK based. These procedures were proved to be suitable to synthesize the aromaticsubstited ehtynyl phosphonates, particularly.
Advisors
Oh, Dong-Youngresearcher오동영researcher
Publisher
한국과학기술원
Issue Date
1990
Identifier
67086/325007 / 000881028
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 화학과, 1990.2, [ v, 59 p. ]

URI
http://hdl.handle.net/10203/32557
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=67086&flag=t
Appears in Collection
CH-Theses_Master(석사논문)
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