Mophology of cholesteryl amphiphile-bilayer aggregates = 콜레스테릴 양친매성 분자로 구성된 이중층 집합체의 구조

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To explore the morphology of bilayer aggregates formed by cholesteryl amphiphiles, various cholesterol-containing amphiphiles having different spacer groups were synthesized from cholesterol. The synthesized amphiphiles were as follows: $$CH_2=C(CH_3)CO_2CH_2CH_2\stackrel{+}{N}(CH_3)_2(CH_2)_{10}CO_2CHOL\;Br^-\;(CHODAMA-10),\; CH_2=C(CH_3)CO_2CH_2CH_2 \stackrel{+}{N}(CH_3)_2(CH_2)_5CO_2CHOL\;Br^-\;\; (CHODAMA-5),\; (CH_3)_2CHCO_2CH_2CH_2\stackrel{+}{N} (CH_3)_2 (CH_2)_{10}CO_2CHOL\; Br^-\;\;\; (CHODABU),\; CH_2=CHCO_2(CH_2CH_2O)_2CH_2CH_2\stackrel{+}{N} (CH_3)_2CH_2CO_2CHOL\; Br^-\; (CHODAMA-OXY-3),\; CH_2=CHCO_2CH_2CH_2OCH_2CH_2\stackrel{+}{N} (CH_3)_2CH_2CO_2CHOL\;Br^-\;(CHODAMA-OXY-2),\;\mbox{and}\; HOCH_2CH_2\stackrel{+}{N}(CH_3)_2(CH_2CH_2O)_3CH_2CH_2 CO_2CHOL\;Br^-\;(CH-DDAUN)$$ ring moiety, $C_{27}H_{45}$. These cholesteryl amphiphiles were soluble in water and formed well developed stable bilayer aggregates upon sonication. Morphology of aqueous monomeric or polymeric amphiphilic bilayer aggregates was investigated by optical and electron microscopy, spectroscopic method, differential scanning calorimetry and viscosity measurement. Hydrophobic $C_5$ or $C_{10}$ hydrocarbon spacers of CHODAMA-5, CHODAMA-10 and CHODABU are embeded into the hydrophobic cholesterol ring region. However, the hydrophilic oxyethylene spacers of CHODAMA-OXY-3 and CHODAMA-OXY-2 are fully extended to the outside of the cholesterol rings. Tubular or rodlike aggregates were predominantly formed from these cholesteryl amphiphiles, and initially vesicle formations were not observed in all cases. Tubules formed by CHODABU was very rigid and stacked, and changed to myelin-like multilamellars and finally to the large vesicles according to aging time. Monomeric CHODAMA-5 was observed as random clusters, but poly(CHODAMA-5) formed the large extended ordered aggregates by the entanglement of rods. Monomeric and polymeric CHODAMA-10 formed disklike and spheric folded rodlike aggregates. How...
Advisors
Cho, I-Whan조의환
Description
한국과학기술원 : 화학과,
Publisher
한국과학기술원
Issue Date
1988
Identifier
61130/325007 / 000835157
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 화학과, 1988.2, [ x, 113 p. ]

URI
http://hdl.handle.net/10203/31300
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=61130&flag=dissertation
Appears in Collection
CH-Theses_Ph.D.(박사논문)
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