Distillation columns are energy intensive separation units in the chemical plants. From an economic point of view, they are prime candidates for the application of the advanced control techniques. In this work, control structure synthesis for distillation columns is investigated in the general decentralized control approach. There are an infinite number of distillation control structures theoretically wich can be produced through structural transformation from a base structure. Each control structure makes up a different decentralized control system around a distillation column. These control systems have several important differences in the degree of interaction, sensitivity to disturbances, robustness against uncertainties, integrity(sensor/actuator failure tolerance), technical implementation complexities and etc. Many transformed control structures are evaluated from two standpoints: Interaction and Disturbance Sensitivity. Although there are brief comments on distillation column from each standpoint, there have been few researches from even interaction viewpoint using a dynamic interaction measure and a rigorous closed-loop performance measure as well. This study have applied ROSM(Relative Output Sensitivity Matrix) and RISM (Relative Input Sensitivity Matrix) as interaction analysis tools. Disturbance Sensitivity is investigated in three operation modes, i. e., open-loop mode, one-point control mode and two-point control mode. SVA(Singular Value Analysis) concept at two-point control mode is introduced to evaluate disturbance rejection capability and set-point tracking performance between control structures. Dynamic simulations are carried out for all cases. The purpose of this study is to select the best control structures which have the least interactions and are insensitive to disturbances and infer general features of specific control structures of a distillation column.