Fabrication of hierarchically structured microspheres for surface-enhanced Raman scattering = 표면 증강 라만 산란 효과를 위한 계층적 표면 복잡성을 갖는 입자의 제조

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dc.contributor.advisorYang, Seung-Man-
dc.contributor.advisor양승만-
dc.contributor.authorHwang, Hye-Rim-
dc.contributor.author황혜림-
dc.date.accessioned2011-12-13T01:49:23Z-
dc.date.available2011-12-13T01:49:23Z-
dc.date.issued2011-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=467720&flag=dissertation-
dc.identifier.urihttp://hdl.handle.net/10203/29536-
dc.description학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2011.2, [ v, 47 p. ]-
dc.description.abstractSurface-enhanced Raman scattering (SERS) has been emerged as one of the most promising strategies in chemical and biomolecular detection due to high sensitivity and label-free identification in binding kinetics and cost of metal pattern preparation. In this study, I fabricate microspheres with hierarchical surface nanopatterns using microfluidic device for molecular detection based on surface-enhanced Raman scattering. Briefly, a photocurable silica-ETPTA suspension was emulsified into monodisperse droplets using a microfluidic device composed of two coaxial glass capillaries. The silica particles in each droplet protruded through the interface and spontaneously formed a hexagonal array. After photopolymerization of the droplets, I selectively decorated the exposed areas of the silica particles with silver nanoparticles through silver mirror reaction. The resulting hierarchically structured microspheres showed high sensitivity and fast binding kinetics in molecular detection based on SERS, owing to the dense array of hot spots on each microsphere and high mobility of the microspheres, respectively. Notably, the SERS signals from molecules adsorbed on the microspheres could be detected in both the dried and suspension states. In addition, I demonstrate that the SERS-active microspheres can be functionalized into structural colored or magnetoresponsive microspheres for advanced applications.eng
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectMolecular detection-
dc.subjectMicrospheres-
dc.subjectSurface-enhanced Raman scattering-
dc.subjectEmulsions-
dc.subject에멀젼-
dc.subject분자 감지-
dc.subject미세 입자-
dc.subject표면 증강 라만 산란-
dc.titleFabrication of hierarchically structured microspheres for surface-enhanced Raman scattering = 표면 증강 라만 산란 효과를 위한 계층적 표면 복잡성을 갖는 입자의 제조-
dc.typeThesis(Master)-
dc.identifier.CNRN467720/325007 -
dc.description.department한국과학기술원 : 생명화학공학과, -
dc.identifier.uid020093610-
dc.contributor.localauthorYang, Seung-Man-
dc.contributor.localauthor양승만-
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