COMPOSITION FOR REVERSE CONTROL OF CELLULAR SENESCENCE COMPRISING PDK1 INHIBITOR

Abstract

Disclosed is a reverse-cellular senescence inducing method that uses a specific molecular target to revert senescent cells to a young cell state. Specifically, the present invention relates to a reverse-cellular senescence inducing composition comprising a PDK1 (phosphoinositide-dependent kinase-1) inhibitor or a reverse-cellular senescence inducing method comprising applying the PDK1 inhibitor. The PDK1 is a protein that regulates both mTOR and NF-kB, which are key signaling proteins involved in the cellular senescence. Thus, the PDK1 is a key protein that determines growth, division and a senescence associated secretory phenotype (SASP) of cells. Temporary inhibition of the PDK1 effectively reverses senescent cells into normal young cells. A phenotype of the senescent cells is no longer observed in the reversed cells. Thus, the PDK1 opens up new possibilities for current aging treatment strategies, which have focused on inducing apoptosis of senescent cells. The PDK1 may be usefully used in development of anti-aging substances and an agent for treating age-related diseases.