DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Chung, An-Sik | - |
dc.contributor.advisor | 정안식 | - |
dc.contributor.author | Kim, Shin-Hyoung | - |
dc.contributor.author | 김신형 | - |
dc.date.accessioned | 2011-12-12T08:54:10Z | - |
dc.date.available | 2011-12-12T08:54:10Z | - |
dc.date.issued | 2005 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=243512&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/28041 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 생명과학과, 2005.2, [ iv, 48 p. ] | - |
dc.description.abstract | UVB induces the matrix metalloproteinase (MMP) collagenase, 92-kD gelatinase, and stromelysin, which degrade skin connective tissue and may contribute to premature skin aging (photoageing). α-Lipoic acid (LA) is well known as a potent antioxidant. Due largely to its antioxidant properties, LA has recently been reported to afford protection against oxidative injury. Zymography and Western blot experiments displayed that MMP-1 and MMP-9 protein were increased significantly in UVB irradiated HaCaT cells. However, LA had effects on expressions and activities of MMP-1 and MMP-9 induced by UVB and also attenuated UVB irradiation-induced oxidative stress. We investigated upstream signal transduction pathways of MMPs induction by UVB irradiation. LA inhibited activation of the mitogen-activated protein (MAP) kinases, extracellular signal-regulated kinase (ERK), c-JUN amino-terminal kinase (JNK) and transcription factor AP-1 (cFOS/cJUN) . Our study demonstrates that LA significantly blocks the up-regulation of MMP-1 and MMP-9 by UVB irradiation through the change in redox system. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | UVB | - |
dc.subject | MM-9 | - |
dc.subject | MMP-1 | - |
dc.subject | α-Lipoic acid reductasets | - |
dc.subject | 알파 리포산ase | - |
dc.subject | 자외선 | - |
dc.subject | 엠엠피-9 | - |
dc.subject | 엠엠피-1 | - |
dc.title | (The) effect of α-Lipoic acid on the MMP-1 and MMP-9 activity induced by UVB irradiation | - |
dc.title.alternative | 자외선에 의한 MMP-1과 MMP-9 활성 및 알파 리포산의 억제 효과 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 243512/325007 | - |
dc.description.department | 한국과학기술원 : 생명과학과, | - |
dc.identifier.uid | 020033112 | - |
dc.contributor.localauthor | Chung, An-Sik | - |
dc.contributor.localauthor | 정안식 | - |
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