(A) framework for immune system modeling based on petri nets = 페트리넷 기반 면역시스템 모데링 프레임워크 구축

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The immune system is a complex system which is composed of many cells and the web of interactions between them. To understand the immune system comprehensively, it is necessary not only to make experiments but also to make models which can explain the experimental observations. With immune system models, we can make in silco experiments and predict the result of in vivo or in vitro experimetns for further studies. Until now, a lot of immune models were developed with differential equations or cellular automata, but they deal with one particular immune process or particular disease such as AIDS rather than the whole immune system. Although the immune response is well modeled piece by piece, to find new emergent properties in the system level, we need an integrated model. In this thesis, we made a framework for whole immune system modeling with a continuous Petri net. To show its usefulness, we made an integrated immune model which includes innate, humoral, and cellular immune responses with our framework. With this model, we simulated immune responses against antigen or virus infection and we could reproduce experimental observations. It is expected that many immune system models could be builded and integrated with the framework. With an integrated immune model, we could understand the immune system as a whole and find new emergent properties which could not be seen in seperate models.
Advisors
Lee, Kwang-H.researcher이광형researcher
Description
한국과학기술원 : 바이오시스템학과,
Publisher
한국과학기술원
Issue Date
2004
Identifier
240416/325007  / 020023921
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오시스템학과, 2004.8, [ vi, 31 p. ]

Keywords

IMMUNE SYSTEM MODELINGOTEIN-PROTEIN INTERACTION; TRANSCRIPTION REGULATION; 면역시스템 모델링 단백질 상호작용; 전사정보

URI
http://hdl.handle.net/10203/27095
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=240416&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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