Visible-Light-Induced ortho-Selective Migration on Pyridyl Ring: Trifluoromethylative Pyridylation of Unactivated Alkenes

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dc.contributor.authorJeon, Jinwonko
dc.contributor.authorHe, Yu-Taoko
dc.contributor.authorShin, Sanghoonko
dc.contributor.authorHong, Sungwooko
dc.date.accessioned2019-12-20T07:20:06Z-
dc.date.available2019-12-20T07:20:06Z-
dc.date.created2019-12-02-
dc.date.issued2020-01-
dc.identifier.citationANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.59, no.1, pp.281 - 285-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10203/270071-
dc.description.abstractThe photocatalyzed ortho-selective migration on a pyridyl ring has been achieved for the site-selective trifluoromethylative pyridylation of unactivated alkenes. The overall process is initiated by the selective addition of a CF3 radical to the alkene to provide a nucleophilic alkyl radical intermediate, which enables an intramolecular endo addition exclusively to the ortho-position of the pyridinium salt. Both secondary and tertiary alkyl radicals are well-suited for addition to the C2-position of pyridinium salts to ultimately provide synthetically valuable C2-fluoroalkyl functionalized pyridines. Moreover, the method was successfully applied to the reaction with P-centered radicals. The utility of this transformation was further demonstrated by the late-stage functionalization of complex bioactive molecules.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.titleVisible-Light-Induced ortho-Selective Migration on Pyridyl Ring: Trifluoromethylative Pyridylation of Unactivated Alkenes-
dc.typeArticle-
dc.identifier.wosid000496512800001-
dc.identifier.scopusid2-s2.0-85075331190-
dc.type.rimsART-
dc.citation.volume59-
dc.citation.issue1-
dc.citation.beginningpage281-
dc.citation.endingpage285-
dc.citation.publicationnameANGEWANDTE CHEMIE-INTERNATIONAL EDITION-
dc.identifier.doi10.1002/anie.201912746-
dc.contributor.localauthorHong, Sungwoo-
dc.contributor.nonIdAuthorHe, Yu-Tao-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthoralkenes-
dc.subject.keywordAuthorheterocycles-
dc.subject.keywordAuthorphotochemistry-
dc.subject.keywordAuthorradicals-
dc.subject.keywordAuthorreaction mechanisms-
dc.subject.keywordPlusC-H FUNCTIONALIZATION-
dc.subject.keywordPlusC(SP(3))-H BONDS-
dc.subject.keywordPlusMETAL-FREE-
dc.subject.keywordPlusALKYLATION-
dc.subject.keywordPlusARYLATION-
dc.subject.keywordPlusSALTS-
dc.subject.keywordPlusATOM-
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CH-Journal Papers(저널논문)
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