Reconstruction of context-specific genome-scale metabolic models using multiomics data to study metabolic rewiring

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Metabolic rewiring or reprogramming is the alteration of metabolism in living organisms, leading to disordered states aberrant from homeostasis. As large amounts of omics data become available, complex mechanisms leading to or driven by metabolic rewiring of cells can be better understood using reconstructed context-specific genome-scale metabolic models (GEMs). Here, we review recent advances in reconstructing context-specific GEMs for studying metabolic rewiring of human cells or tissues, from generic GEMs and omics databases to multiomics data integration methods. Also, we review recent studies that use context-specific GEMs to obtain insights such as identifying key regulators or therapeutic targets. Analyses of recent trends indicate the importance of integrating context-specific GEMs with multiscale networks for understanding metabolic diseases and advancing precision medicine.
Publisher
Elsevier BV
Issue Date
2019-06
Language
English
Article Type
Review
Citation

Current Opinion in Systems Biology, v.15, pp.1 - 11

ISSN
2452-3100
DOI
10.1016/j.coisb.2019.02.009
URI
http://hdl.handle.net/10203/269081
Appears in Collection
CBE-Journal Papers(저널논문)
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