Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation

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Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, "topodiscs", are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2019-09
Language
English
Article Type
Article
Citation

NANOSCALE, v.11, no.35, pp.16214 - 16221

ISSN
2040-3364
DOI
10.1039/c9nr06267j
URI
http://hdl.handle.net/10203/267843
Appears in Collection
CH-Journal Papers(저널논문)
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