Genomic GPS: using genetic distance from individuals to public data for genomic analysis without disclosing personal genomes

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Genomic global positioning system (GPS) applies the multilateration technique commonly used in the GPS to genomic data. In the framework we present here, investigators calculate genetic distances from their samples to reference samples, which are from data held in the public domain, and share this information with others. This sharing enables certain types of genomic analysis, such as identifying sample overlaps and close relatives, decomposing ancestry, and mapping of geographical origin without disclosing personal genomes. Thus, our method can be seen as a balance between open data sharing and privacy protection.
Publisher
BMC
Issue Date
2019-08
Language
English
Article Type
Article
Citation

GENOME BIOLOGY, v.20, no.1

ISSN
1474-760X
DOI
10.1186/s13059-019-1792-2
URI
http://hdl.handle.net/10203/267530
Appears in Collection
MA-Journal Papers(저널논문)
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