Densely aligned carbon nanotube-based biosensor for electrical detection of alzheimer’s disease biomarkers = 고밀도 정렬 탄소나노튜브 기반 바이오센서를 이용한 알츠하이머 바이오 마커 검출

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Biosensors are used in various applications such as disease diagnosis, environmental monitoring, drug development, and food safety. Recently, as the medical paradigm has changed from the treatment of disease to the diagnosis and prevention, the biosensor research related to the early diagnosis of intractable disease is actively being studied. Especially in the case of Alzheimer's disease, there is still no definitive treatment because there is no way to make an early diagnosis of Alzheimer's disease but discovered when the disease is already advanced. For early diagnosis of Alzheimer's disease, it is essential that highly sensitive sensors capable of detecting very low concentrations of biomarkers of several pM or less are essential. Transducers that convert the detection of biomaterials into electrical signals in biosensors are very important factors in increasing the sensitivity of sensors. In this paper, a biosensor was fabricated using aligned carbon nanotubes as transducer materials. Carbon nanotubes are suitable for the detection of minute changes on the surface due to their high electrical conductivity, the size of a few nanometers similar to a biomolecule, and the high surface-to volume ratio. However, since the resistance of tube-tube junction of CNT is about 10 times higher than the resistance of the carbon nanotube itself, the junction point may degrade the performance of the sensor. To solve this problem, we fabricated a biosensor with very high sensitivity and uniformity by aligning carbon nanotubes using the Langmuir-Blodgett method. The sensor has a detection limit of 139fM and 1.1fM for amyloid beta and tau protein, respectively. It is expected that the production of these sensors will provide a direction for early diagnosis of Alzheimer's disease.
Advisors
Park, Steveresearcher스티브 박researcher
Description
한국과학기술원 :신소재공학과,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 신소재공학과, 2019.2,[iv, 42 p. :]

Keywords

Biosensor▼acarbon nanotube▼ahighly dense alignment▼afunctionalization of CNT▼aalzheimer’s disease▼aamyloid beta▼atau protein; 바이오 센서▼a탄소나노튜브▼a고밀도 정렬▼a탄소나노튜브의 표면 처리▼a알츠하이머▼a아밀로이드 베타▼a타우 단백질

URI
http://hdl.handle.net/10203/266465
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=843300&flag=dissertation
Appears in Collection
MS-Theses_Master(석사논문)
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