Photoelectrocatalytic inhibition of amyloid self-assembly by hematite photoanode = 산화철 광전극을 이용한 광전기화학적 아밀로이드 자기조립 억제 연구

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The abnormal self-assembly of $\beta-amyloid$ ($A\beta$) peptides into $\beta$-sheet-rich amyloid aggregates and subsequent accumulation in the brain are pathological hallmark of Alzheimer’s disease (AD). Various kinds of photo-active inhibitor have been introduced to suppress the $A\beta$ aggregation using light sources; however, their application has been limited due to their incomplete metabolism in human body and poor permeability to blood brain barrier. Recently, there has been a report that the development of micrometer-scale implantable LED module has been successful, which motivated us to develop photoelectrode-based therapy of AD. Herein, we report on visible light-active hematite ($\alpha-Fe_2O_3$)-based photoanode as an inhibitor for suppression of $A\beta$ aggregation. The synthesized hematite photoanode has a suitable band gap (2.1eV) to absorb visible light and showed effective photoelectrocatalytic activity generating reactive oxidative species(ROS) including superoxide ion(O2·-) and hydroxyl radical(OH·). We demonstrated that when applying a bias and LED to the hematite photoanode, it exhibited effective inhibitory effect on $A\beta$ aggregation owing to hole-derived radical, OH·. Modification of hematite photoanode using co-catalyst, Co-Pi, accelerated the production of OH· and inhibitory effect on $A\beta$ aggregation. Moreover, the hematite photoanode is not only biocompatible, but also effective in suppressing $A\beta-induced$ cytotoxicity. This work gives hints to the potential of utilizing the visible light-active hematite photoanode as an inhibitor of $A\beta$ aggregation for treatment of AD in the future.
Advisors
Park, Chan Beumresearcher박찬범researcher
Description
한국과학기술원 :신소재공학과,
Publisher
한국과학기술원
Issue Date
2016
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 신소재공학과, 2016.8,[v, 47 p. :]

Keywords

$\beta$-amyloid▼ainhibition of aggregation▼aphotoelectrocatalytic▼ahematite photoanode▼ahole-derived radical; 베타 아밀로이드▼a응집현상 억제▼a광전기화학적▼a산화철 광전극▼a하이드록실 라디칼

URI
http://hdl.handle.net/10203/266454
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=849897&flag=dissertation
Appears in Collection
MS-Theses_Master(석사논문)
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