Metabolic engineering of corynebacterium glutamicum for production of glutaric acid = 대사공학을 이용한 코리네박테리움 글루타미쿰에서의 글루타르산 생산 연구

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Environmental problems including climate change are urging us to establish sustainable chemical industry that produces chemicals, fuels and materials from renewable biomass using eco-friendly methods. The C5 platform chemicals including 5-aminovaleric acid (AVA) and glutaric acid can be used to produce valerolactam, 5-hydroxyvalerate and 1,5-pentanediol all in which can be used in turn for polyester, polyamide and polyol manufacture. The industrial strain, C. glutamicum, is widely used for global L-lysine, L-gluatmate and cadaverine market demand. Here, an efficient method to produce glutaric acid production by metabolic engineering of C. glutamicum is presented. The L-lysine biosynthetic pathway was extended by heterologous expression of L-lysine catabolic pathway to produce 100.22 g/L glutaric acid in a laboratory-scale bioreactor.
Advisors
Lee, Sang Yupresearcher이상엽researcher
Description
한국과학기술원 :생명화학공학과,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2019.2,[iv, 64 p. :]

Keywords

Corynebacterium glutamicum▼ametabolic engineering▼aglutaric acid; 코리네박테리움 글루타미쿰▼a대사공학▼a글루타르산

URI
http://hdl.handle.net/10203/266341
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=843270&flag=dissertation
Appears in Collection
CBE-Theses_Master(석사논문)
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