Combating drug resistance by controlled release of BODIPY based nanoparticle and synergistic chemo-photodynamic effect = 보디피에 기반한 나노파티클의 방출조절과 화학 광역학치료의 복합적 상승효과를 통한 약물내성 극복

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Chemo-photodynamic therapy has received rapidly growing interests as one of the promising drug resistant cancer treatment. Herein, we developed a novel theranostic nanoscale drug delivery system (nDDS), which combines chemotherapy and photodynamic therapy (PDT) into modified single platform to achieve synergistic effects of these therapies on the treatment of drug resistant cancer cell. We synthesized chemo-photodynamic agents, amphiphilic benzyl poly (ethylene glycol)-diiodo substituted BODIPY conjugated with cisplatin (bPEG-DIBOC). The bPEG-DIBOC act as drug delivery system of photosensitizer and cisplatin. The cellular cisplatin uptake derived from the bPEG-DIBOC nanoparticles was much higher than that derived from cisplatin in A549 lung cancer cells and cisplatin-resistant A549/DDP lung cancer cells. The level of cellular reactive oxygen species (ROS) in the cell treated with bPEG-DIBOC was significantly elevated after light irradiation. Through these properties, the bPEG-DIBOC showed distinguished anticancer effects against A549/DDP cells with much lower concentration than free cisplatin. Consequently, this study proposes the outstanding potential of nDDS-based chemo-photodynamic therapeutic agent to circumvent drug resistance.
Advisors
Kim, Yeu-Chunresearcher김유천researcher
Description
한국과학기술원 :생명화학공학과,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2019.2,[iii, 34 p. :]

Keywords

Chemo-photodynamic therapy▼adrug delivery system▼asynergistic effect▼adrug resistance; 화학 광역학치료▼a약물전달▼a시너지 효과▼a약물내성

URI
http://hdl.handle.net/10203/266307
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=843217&flag=dissertation
Appears in Collection
CBE-Theses_Master(석사논문)
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