Designing SERS-active microgels containing highly concentrated gold nanoparticles for selective detection of small molecules = 라만 산란 기반의 선택적 분자 검출을 위한 고농축 금나노입자가 담지된 마이크로젤의 설계

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Surface-enhanced Raman scattering (SERS) can enhance Raman signals through adsorbing target molecules on the surface of metal nanostructures with strong electromagnetic fields. However, it is difficult to deposit target molecules without complicated pre-treatment steps. In this research, we introduce SERS-active microgels containing highly-concentrated gold nanoparticles. Water-in-oil-in-water double emulsion drops were prepared by counter-flow-microfluidics. The core of the drops contain gold nanoparticles and hydrogel precursors. As imposing positive osmotic pressure on the drops, the water in the core flows out and the concentration of gold nanoparticles increased by a factor of 30-40. Finally, the highly-concentrated gold nanoparticles are trapped through gelation of the core under UV. The microgel system of SERS substrates worked as a molecular sieve and it provided molecular selectivity. Well-distributed gold nanoparticles with high concentration provide signal enhancement and reproducibility.
Advisors
Kim, Shin-Hyunresearcher김신현researcher
Description
한국과학기술원 :생명화학공학과,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2019.2,[ii, 41 p. :]

Keywords

SERS▼adouble emulsions▼amicrofluidics▼aosmotic pressure▼agold nanoparticles; 표면증강라만산란▼a이중액적▼a미세유체▼a삼투압▼a금 나노입자

URI
http://hdl.handle.net/10203/266301
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=843226&flag=dissertation
Appears in Collection
CBE-Theses_Master(석사논문)
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