Role of the conditioned stimulus input to lateral amygdala in auditory fear memory retrieval = 청각 공포기억 회상에서 편도체로 전달되는 조건화 자극 전달회로의 역할 연구

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During auditory fear conditioning, secondary auditory cortex(AuV) and auditory thalamus(MGm/PIN) convey conditioned stimulus to lateral amygdala(LA). Auditory pathways to LA are well-studied, and LA has important role to recall auditory fear memory. However, role of these pathways during memory retrieval is unknown. To verify necessity of these pathways, inhibiting terminal of auditory pathways in LA area was conducted by two third version of optogenetic techniques; Halorhodopsin(eNpHR3.0) and Archaerhodopsin(eArch3.0). As the result, auditory fear memory was recalled normally during inhibition with eNpHR3.0, while freezing level decrease by inhibition with eArch3.0 during tone release. Furthermore, at another retrieval session after 24-hours (second retrieval), memory retrieval was blocked also. Even mice are conducted re-training, impairment of memory retrieval didn't recover. This impairment is not an effect of cellular damage by virus or over-expression of proteins. According to result of Arch group, I infer that auditory input to LA is required for memory retrieval. For ensuring the state, recoding the activity of input terminal during memory retrieval is needed.
Advisors
Han, Jin-Heeresearcher한진희researcher
Description
한국과학기술원 :생명과학과,
Publisher
한국과학기술원
Issue Date
2018
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2018.2,[iii, 23 p. :]

Keywords

Auditory fear conditioning▼amemory retrieval▼aauditory input pathway▼aoptogenetics▼ahalorhodopsin▼aarchaerhodopsin; 청각 공포 학습▼a기억 회상▼a청각 정보 전달 회로▼a광유전학▼a할로로돕신▼a알케로돕신

URI
http://hdl.handle.net/10203/266284
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=733866&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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