Fiber optic SERS probe with gold nanoislands for biomolecule detection using repeated solid-state dewetting = 반복적 비젖음 현상을 이용한 금 나노섬 구조를 갖는 생체분자검출용 표면증강라만분광 광섬유 프로브

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Fiber optic SERS probe enables remote biomolecule sensing through an optical fiber with high repeatability by utilizing the whole plasmonic nanostructure on the fiber tip as a SERS-active substrate with advantages of an optical fiber such as minimal invasiveness, flexibility, and biocompatibility. These remarkable characteristics of fiber optic SERS probe are comparable to labeled metal nanoparticles that have disadvantages of toxicity and accumulation for in vivo biosensing application. However, conventional plasmonic nanostructure on the fiber tip had limitations such as the necessity of expensive fabrication method or hardness for the realization of sufficient plasmonic ‘hot spot’ with cost-effective methods. This research proposed a novel fiber optic SERS probe with multiple strong plasmonic ‘hot spots’ on the fiber tip by gold nanoislands using cost-effective repeated solid-state dewetting of thin gold film. Proposed fiber optic SERS probe enables 100nM limit of detection (LOD) for crystal violet molecules. Furthermore, detection of 1μM folic acid known as a cancer biomarker was successful. Proposed fiber optic probe will provide opportunities for in vivo biosensing using fiber through SERS measurement.
Advisors
Jeong, Ki-Hunresearcher정기훈researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2018
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2018.8,[viii, 52 p. :]

Keywords

SERS▼afiber optic probe▼ain vivo biomolecule detection▼arepeated solid-state dewetting; 표면증강라만분광▼a광섬유 프로브▼a생체내 분자검출▼a반복적 고체상 비젖음

URI
http://hdl.handle.net/10203/266183
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=828490&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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