Surface functionalization of microelectrode array for photothermal inhibition of in vitro neural activity using Indocyanine Green (ICG) = 인도사이아닌그린(ICG)를 통한 광열 신경 억제효과가 가능한 미세전극칩 표면 기능화에 관한 연구

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Over the past decades, there has been an increasing demand for neural stimulation platforms owing to their potential for applications in treating brain diseases and neuroscience research. To that end, many a neural stimulation technique has emerged, such as the ones that use chemicals, electricity and light. Amongst them, a combined use of light and photothermal materials drew a great deal of attention for their high spatiotemporal resolution and safety. In this study, the objective is to use the photothermal property of a FDA-approved NIR dye Indocyanine Green, immobilized on a MEA substrate via layer-by-layer assembly, for inhibiting neural activity. It was demonstrated that electrical firing of hippocampal neurons cultured on ICG-chip could be suppressed when exposed to near infrared stimuli. This study suggested the feasibility of using a novel material, ICG for optical neuromodulation.
Advisors
Nam, Yoonkeyresearcher남윤기researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2017
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2017.2,[vi, 72 p. :]

Keywords

layer-by-layer assembly▼aIndocyanine Green▼aphotothermal substrate▼asurface modification▼amicroelectrode array▼aneuromodulation; 층별조립법▼a인도사이아닌그린▼a광열기판▼a표면처리▼a미세전극어레이▼a신경세포활성화조절

URI
http://hdl.handle.net/10203/266152
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=867008&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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