Time-dependent retention of nanotopographical cues in differentiated neural stem cells

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Exposure time to mechanical cues is important to properly modulating stem cell fate. The phenomenon in which the cells retain information from past stimuli, the so-called "time-retention effect", has become one of the major factors to modulate stem cell differentiation with different mechanical cues. Using a stress-responsive and tunable nanowrinkle topography, we investigated the effects of time-dependent retention of a nanotopographical cue on differentiating the neural stem cells (NSCs). After removing nanotopography used to induce hNSCs neuronal differentiation, we observed that differentiated NSCs exposed to the nanotopography for longer times retained their neural features compared to NSCs exposed shorter. We concluded that the NSCs could retain the nanotopographical stimuli depending on the dosing time during differentiation, suggesting the impact of the time-retention effect in controlling stem cell fate.
Publisher
AMER CHEMICAL SOC
Issue Date
2019-08
Language
English
Article Type
Article
Citation

ACS BIOMATERIALS SCIENCE & ENGINEERING, v.5, no.8, pp.3802 - 3807

ISSN
2373-9878
DOI
10.1021/acsbiomaterials.8b01057
URI
http://hdl.handle.net/10203/266093
Appears in Collection
BiS-Journal Papers(저널논문)
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