RIG-I ligands study as effective antiviral and anti-tumor immunotherapy = 항바이러스 및 항암 면역치료제로써의 효과적인 RIG-I 리간드에 관한 연구

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Retinoic acid-inducible gene I (RIG-I) is a cytosolic receptor of viral RNA and recognizes double-stranded viral RNAs (dsRNAs) containing two or three 5’ phosphates. Critical role of viral RNAs is recognizing viral RNAs and induces type I interferons. A few reports of 5’- PPP-independent RIG-I agonists have emerged, but little is known about the molecular principles underlying their recognition. We recently found that the bent duplex RNA from the influenza A panhandle promoter activates RIG-I even in the absence of a 5’-triphosphate moiety. Here, we report that noncanonical synthetic RNA oligonucleotides containing G-U wobble base pairs that form a bent helix can exert RIG-I-mediated antiviral and anti-tumor effects in a sequence- and site-dependent manner. We also implies that structural dynamics of synthetic RNAs conserving G-U wobble base pairs by using NMR spectroscopy. We present synthetic RNAs that have been systematically modified to enhance their efficacy and outline the basic principles for engineering RIG-I agonists applicable to immunotherapy.
Advisors
Choi, Byong-seokresearcher최병석researcher
Description
한국과학기술원 :화학과,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 화학과, 2019.2,[ix, 100 p. :]

Keywords

RIG-I▼atriphosphate▼abent RNA duplex▼aimmunotherapy; RIG-I▼a삼인산▼a이중나선 굽힘▼a면역치료제

URI
http://hdl.handle.net/10203/265512
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842450&flag=dissertation
Appears in Collection
CH-Theses_Ph.D.(박사논문)
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