Development of direct C-H amination using amines via transition metal-mediated cross-dehydrogenative coupling = 전이금속 매개체와 아민의 교차-탈수소화 짝지음 반응을 통한 탄소-수소 결합 아미노화 반응에 관한 연구

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Cross-dehydrogenative couplings (CDCs) have become one of the most straightforward protocols in the C-H bond functionalizations, showing step- and atom-efficiency without need of pre-functionalization of substrates and reactants. However, catalytic C-H amination procedures based on the CDC strategy by employing amine reactants are considered to be challenging mainly due to the highly nucleophilic character of parent amines to inhibit the catalytic turnovers and the difficulty in optimizing proper oxidative conditions. In spite of these concerns, recent efforts have led to notable advances in the C-H amination procedures, particularly in the intermolecular reaction system. In this thesis, we address the development of the transition-metal-mediated direct C-H amination of arenes with anilines, alkylamines and even ammonia. The reactions do not require pre-functionalization of the amine coupling partners. Thus, these C-N bond formation represent the unique examples that is compatible with external oxidants to afford aminated products. Mechanistic details, such as the isolation and characterization of key intermediates are also discussed.
Advisors
Chang, Sukbokresearcher장석복researcher
Description
한국과학기술원 :화학과,
Publisher
한국과학기술원
Issue Date
2018
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 화학과, 2018.2,[ii, 73 p. :]

Keywords

cross-dehydrogenative coupling▼aoxidative C-H amination▼aanilines▼aalkylamines▼aammonia; 교차-탈수소화 짝지음 반응▼a산화적 탄소-수소 결합 아미노화 반응▼a아닐린▼a알킬아민▼a암모니아

URI
http://hdl.handle.net/10203/265503
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=867931&flag=dissertation
Appears in Collection
CH-Theses_Ph.D.(박사논문)
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